Bergamot

Also known as: Citrus bergamia, bergamot polyphenol fraction, BPF, Bergavit

Grade B — Moderate Evidencepolyphenolheartmetabolic
500–1000 mg BPFWith meals. Consistent daily use (4-12 weeks). Morning preferred.

Impressive lipid-modifying polyphenol: 30% LDL reduction in RCTs. Natural HMG-CoA reductase inhibitor (statin-like mechanism).

❤️Heart Health
Last reviewed: 2026-03-11

Evidence

Grade B

Studies

2

Interactions

3

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

WarfarinModerate

Furanocoumarins may inhibit CYP3A4; monitor INR

Calcium channel blockersModerate

CYP3A4 inhibition may increase drug levels

StatinsLow

Additive LDL-lowering; safe combination

⚠️ Important Notes

  • Standardized BPF extract is different from essential oil
  • CYP3A4 inhibition: review concurrent medications
  • Citrus allergy: possible cross-reactivity

Clinical Evidence (2 studies)

BPF for dyslipidemia

Mollace V et al. (2011) — Fitoterapia

1,000mg/day: 30% LDL reduction, 29% TG reduction, 40% HDL increase; RCT

View on PubMed

Bergamot polyphenols for dyslipidemia: systematic review

Toth PP et al. (2016) — Front Pharmacol

Consistent improvement across lipid parameters

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Bergamot.

Berberine

Grade A

Potent plant alkaloid with metformin-like effects on blood sugar. Also activates AMPK (longevity pathway). Multiple drug interactions.

❤️ Heart Health

Psyllium Husk

Grade A

Soluble fiber with FDA-approved health claim for cholesterol reduction. Also effective for blood sugar control and constipation.

❤️ Heart Health

Garlic / Allicin

Grade A

Strong RCT evidence for blood pressure reduction (~8-9/5-6 mmHg) and cold prevention (64% reduction). Aged extract preferred for CV.

❤️ Heart Health

Related Supplements

Berberine

Grade A — Strong Evidence

Potent plant alkaloid with metformin-like effects on blood sugar. Also activates AMPK (longevity pathway). Multiple drug interactions.

Resveratrol

Grade B — Moderate Evidence

SIRT1 activator commonly combined with NMN/NR. Human evidence for metabolic improvement and cognitive support. Lipid-soluble — take with fat.

Psyllium Husk

Grade A — Strong Evidence

Soluble fiber with FDA-approved health claim for cholesterol reduction. Also effective for blood sugar control and constipation.

Beta-Glucan

Grade B — Moderate Evidence

Dual-purpose supplement: yeast-derived for immune support (250mg), oat-derived for cholesterol (3g). Both well-supported by RCTs.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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