Myo-Inositol

Also known as: inositol, myo inositol, inositol powder

Grade B — Moderate Evidencevitamin-likemoodmental health
2000–4000 mgSplit AM/PM with food

Naturally occurring sugar alcohol with strong evidence for PCOS, panic disorder, and OCD. Gentle anxiolytic. Very safe at standard doses.

😊Mood🧘Stress & Anxiety⚡Energy❤️Heart Health
Last reviewed: 2026-03-11

Evidence

Grade B

Studies

3

Interactions

2

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

LithiumModerate

Inositol may counteract lithium mechanism in bipolar disorder. Discuss with psychiatrist.

SSRIsLow

May have additive or complementary effects on serotonin signaling.

⚠️ Important Notes

  • GI upset common at high doses — start low and titrate
  • Most evidence for PCOS and anxiety; less robust for other uses
  • 4:1 ratio of myo-inositol:D-chiro-inositol may be optimal for PCOS

Clinical Evidence (3 studies)

Inositol versus placebo for panic disorder

Benjamin J et al. (1995) — J Clin Psychopharmacol

Inositol significantly superior to placebo for reducing panic attack frequency and severity

View on PubMed

Myo-inositol in PCOS: systematic review and meta-analysis

Unfer V et al. (2016) — Gynecol Endocrinol

Myo-inositol improves insulin sensitivity, ovulation rate, and hormonal profile in PCOS

View on PubMed

Inositol for obsessive-compulsive disorder

Fux M et al. (1996) — Am J Psychiatry

High-dose inositol (18g) significantly improved OCD symptoms vs placebo

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Myo-Inositol.

Tongkat Ali

Grade C

Southeast Asian herb with emerging evidence for cortisol reduction and hormonal support.

⚡ Energy😊 Mood🧘 Stress & Anxiety

Saffron

Grade A

Potent natural antidepressant with multiple RCTs showing comparable efficacy to fluoxetine at just 30mg/day. Also supports eye health.

😊 Mood

Related Supplements

Tongkat Ali

Grade C — Preliminary

Southeast Asian herb with emerging evidence for cortisol reduction and hormonal support.

Ashwagandha

Grade A — Strong Evidence

Ayurvedic adaptogen with strong clinical evidence for cortisol reduction (15-30%), stress relief, and exercise performance.

Rhodiola Rosea

Grade B — Moderate Evidence

Adaptogenic herb with strong evidence for reducing stress-related fatigue. Comparable to low-dose antidepressants for mild depression.

Magnesium Glycinate

Grade A — Strong Evidence

Highly bioavailable form of magnesium. Strong evidence for sleep quality, muscle relaxation, and stress reduction. Most adults are deficient.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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