NMN (Nicotinamide Mononucleotide)

Also known as: NMN, nicotinamide mononucleotide, β-NMN

Grade B — Moderate EvidenceNAD+ precursorlongevity
250–500 mgMorning on empty stomach. NAD+ is circadian-regulated; AM dosing aligns with natural rhythms.

Nicotinamide Mononucleotide (NMN) is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme essential for cellular energy production, DNA repair, and sirtuin activation. NAD+ levels decline significantly with age, and this decline is implicated in many aspects of aging. While animal studies have shown remarkable anti-aging effects, human evidence is still building. NMN has become one of the most discussed longevity supplements.

TL;DR: NAD+ precursor with multiple human RCTs showing elevated blood NAD+ and improved physical performance. Exciting longevity candidate.

🧬Longevity⚡Energy
Last reviewed: 2026-03-11

Evidence

Grade B

Studies

3

Interactions

1

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

ChemotherapyModerate

NAD+ boosting may theoretically support cancer cell survival — consult oncologist

⚠️ Important Notes

  • Rapidly evolving research field
  • Long-term safety beyond 12 months not fully established
  • Often combined with TMG for methylation support

Clinical Evidence (3 studies)

NMN safe and effective; increased NAD levels and physical performance

Yi L et al. (2023) — GeroScience

NMN 300-900mg safe and effective in multicenter RCT

View on PubMed

NMN improved walking speed and NAD+ in older adults

Igarashi M et al. (2022) — NPJ Aging

NMN 250mg for 12 weeks improved walking speed

View on PubMed

NMN in postmenopausal women with prediabetes

Yoshino M et al. (2021) — Science

Improved muscle insulin signaling

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of NMN (Nicotinamide Mononucleotide).

Taurine

Grade B

Conditionally essential amino acid. Landmark 2023 Science paper showed it extends healthy lifespan in multiple species.

🧬 Longevity⚡ Energy

NR (Nicotinamide Riboside)

Grade B

NAD+ precursor with strong human RCT evidence for NAD+ elevation. Unique cardiovascular benefits: reduced arterial stiffness and blood pressure.

🧬 Longevity⚡ Energy

Resveratrol

Grade B

SIRT1 activator commonly combined with NMN/NR. Human evidence for metabolic improvement and cognitive support. Lipid-soluble — take with fat.

🧬 Longevity

Related Supplements

NR (Nicotinamide Riboside)

Grade B — Moderate Evidence

NAD+ precursor with strong human RCT evidence for NAD+ elevation. Unique cardiovascular benefits: reduced arterial stiffness and blood pressure.

Taurine

Grade B — Moderate Evidence

Conditionally essential amino acid. Landmark 2023 Science paper showed it extends healthy lifespan in multiple species.

CoQ10 (Ubiquinol)

Grade A — Strong Evidence

Critical for mitochondrial energy production. Q-SYMBIO trial showed 43% cardiovascular mortality reduction in heart failure. Depleted by statins.

PQQ (Pyrroloquinoline Quinone)

Grade C — Preliminary

Stimulates mitochondrial biogenesis (creation of new mitochondria). Best paired with CoQ10. Still early research.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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