Chlorella

Also known as: chlorella vulgaris, chlorella pyrenoidosa, broken-cell chlorella

Grade C — Preliminarysuperfooddetoximmune
2000–6000 mgMorning with food

Chlorella is a single-celled green algae rich in chlorophyll, protein, vitamins, and minerals with evidence for heavy metal detoxification and immune modulation. Clinical trials show reductions in dioxin levels in breast milk, improved immune markers (increased NK cell activity), and modest reductions in blood pressure and cholesterol. Its unique Chlorella Growth Factor (CGF) contains nucleic acids that may support cellular repair. "Broken cell wall" processing is necessary for nutrient accessibility.

TL;DR: Green algae rich in chlorophyll, protein, iron, and B12. Evidence for immune support and metabolic markers. Broken-cell wall form required for bioavailability. Complementary to spirulina.

🛡️Immunity🦠Gut Health🧬Longevity
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade C

Studies

2

Interactions

2

Forms

1

Evidence Rating: Grade C — Preliminary

Limited human trials, mostly animal or in-vitro data. Promising but not yet proven in robust human studies.

Interaction Warnings

ImmunosuppressantsModerate

Stimulates immune response — may reduce immunosuppressant efficacy.

WarfarinModerate

High vitamin K content may reduce warfarin effectiveness.

Important Notes

  • Must be broken-cell wall form for absorption
  • May cause initial GI upset or green stools
  • Contains significant vitamin K — relevant for warfarin users

Clinical Evidence (2 studies)

Chlorella supplementation and immune function

Kwak JH et al. (2012) — Nutr J

Chlorella 5g/day for 8 weeks significantly increased NK cell activity and IFN-gamma, IL-12, and IL-1beta levels

View on PubMed

Chlorella on serum lipid and glucose profiles

Ebrahimi-Mameghani M et al. (2014) — Complement Ther Med

Chlorella reduced total cholesterol, fasting glucose, and triglycerides significantly vs placebo

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Chlorella.

Sulforaphane

Grade B

Powerful Nrf2 activator from cruciferous vegetables. Evidence for air pollution detoxification and H. pylori eradication.

🧬 Longevity🛡️ Immunity🦠 Gut Health

Turkey Tail Mushroom

Grade B

Most-studied medicinal mushroom for immune support. PSK/PSP polysaccharides are approved as anticancer adjunct therapy in Japan. Strong evidence for immune modulation and gut microbiome support.

🛡️ Immunity🦠 Gut Health🧬 Longevity

Quercetin

Grade B

Versatile flavonoid with senolytic, immune, and anti-inflammatory properties. Zinc ionophore. Phytosome form critical for absorption.

🧬 Longevity🛡️ Immunity

Related Supplements

Sulforaphane

Grade B — Moderate Evidence

Powerful Nrf2 activator from cruciferous vegetables. Evidence for air pollution detoxification and H. pylori eradication.

Turkey Tail Mushroom

Grade B — Moderate Evidence

Most-studied medicinal mushroom for immune support. PSK/PSP polysaccharides are approved as anticancer adjunct therapy in Japan. Strong evidence for immune modulation and gut microbiome support.

NAC (N-Acetyl Cysteine)

Grade B — Moderate Evidence

Precursor to glutathione (master antioxidant). Strong evidence for respiratory health, liver support, and psychiatric conditions.

Spirulina

Grade B — Moderate Evidence

Nutrient-dense cyanobacterium with strong evidence for immune support, lipid improvement, and antioxidant protection. Complete protein source. Quality sourcing is critical to avoid contamination.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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