Glutamine

Also known as: L-glutamine, Gln

Grade B — Moderate Evidenceamino acidgutrecovery
5–10 gMorning and post-workout. Can take on empty stomach or with food.

Conditionally essential amino acid that is the primary fuel for gut lining cells. RCT evidence for IBS and leaky gut.

🦠Gut Health🛡️Immunity💪Muscle & Recovery
Last reviewed: 2026-03-11

Evidence

Grade B

Studies

2

Interactions

2

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

AnticonvulsantsModerate

Glutamine converts to glutamate — theoretical seizure concern in epilepsy

LactuloseLow

May reduce glutamine gut benefit

⚠️ Important Notes

  • Very safe at standard doses
  • Avoid in hepatic encephalopathy (glutamine → ammonia)
  • Primary fuel source for enterocytes

Clinical Evidence (2 studies)

L-glutamine for IBS-D

Zhou Q et al. (2019) — Gut Microbes

5g TID significantly reduced intestinal permeability in IBS-D; RCT

View on PubMed

Glutamine as conditionally essential amino acid

Garlick PJ (2001) — J Nutr

Review establishing glutamine as conditionally essential

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Glutamine.

Ginger

Grade A

Excellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.

🦠 Gut Health🛡️ Immunity

NAC (N-Acetyl Cysteine)

Grade B

Precursor to glutathione (master antioxidant). Strong evidence for respiratory health, liver support, and psychiatric conditions.

🛡️ Immunity🦠 Gut Health

Probiotics

Grade B

Beneficial bacteria for gut health. Strain selection matters — L. rhamnosus GG, B. infantis 35624, and S. boulardii are best-studied.

🦠 Gut Health🛡️ Immunity

Related Supplements

NAC (N-Acetyl Cysteine)

Grade B — Moderate Evidence

Precursor to glutathione (master antioxidant). Strong evidence for respiratory health, liver support, and psychiatric conditions.

Probiotics

Grade B — Moderate Evidence

Beneficial bacteria for gut health. Strain selection matters — L. rhamnosus GG, B. infantis 35624, and S. boulardii are best-studied.

Ginger

Grade A — Strong Evidence

Excellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.

Vitamin D3

Grade A — Strong Evidence

Essential hormone precursor. Most people in northern latitudes are deficient. Strong evidence for immunity, bone health, and mood.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

DoseGrade does not sell supplements and has no affiliate relationships with supplement manufacturers.