Bromelain
Also known as: pineapple enzyme, pineapple extract
Recommended Dosage
500–1000 mg
Bromelain is a complex of proteolytic enzymes derived from pineapple stem that exhibits anti-inflammatory, anti-edema, and fibrinolytic properties. Clinical evidence supports its use for reducing post-surgical and post-traumatic swelling, sinusitis symptoms, and osteoarthritis pain. It works by modulating prostaglandin synthesis, reducing bradykinin levels, and enhancing fibrinolysis. Enteric-coated capsules taken on an empty stomach ensure systemic (not just digestive) anti-inflammatory effects.
TL;DR: Proteolytic enzyme from pineapple with evidence for reducing inflammation, swelling, and pain. Comparable to NSAIDs in some studies. Must take on empty stomach for systemic effects.
Quick Facts
Evidence
Grade B
Studies
2
Interactions
2
Forms
1
Evidence Rating: Grade B — Moderate Evidence
Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.
Interaction Warnings
May enhance anticoagulant effects — monitor with warfarin or aspirin.
May increase absorption of amoxicillin — potentially beneficial.
Important Notes
- Take on empty stomach for systemic anti-inflammatory effects
- Take with meals for digestive enzyme support
- GDU (gelatin dissolving units) indicates potency — look for 2400+ GDU
Clinical Evidence (2 studies)
Bromelain as anti-inflammatory and analgesic agent
Maurer HR (2001) — Cell Mol Life Sci
Bromelain demonstrated significant anti-inflammatory, analgesic, and anti-edema properties comparable to NSAIDs in clinical studies
View on PubMedBromelain for post-surgical inflammation: meta-analysis
Pavan R et al. (2012) — Biotechnol Res Int
Bromelain significantly reduced post-surgical swelling, pain, and healing time
View on PubMedAlternatives to Consider
These supplements target similar goals and may be worth considering alongside or instead of Bromelain.
Ginger
Grade AExcellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.
Black Seed Oil
Grade BWidely studied traditional remedy with strong anti-inflammatory properties from thymoquinone. Evidence for metabolic health, immune modulation, and gut health. Oil form preferred for absorption.
Stinging Nettle Root
Grade BRoot extract may increase free testosterone by inhibiting SHBG binding. Evidence for prostate health and urinary symptoms. Root and leaf have different active compounds and uses. Very safe profile.
Related Supplements
Glutamine
Grade B — Moderate EvidenceConditionally essential amino acid that is the primary fuel for gut lining cells. RCT evidence for IBS and leaky gut.
Ginger
Grade A — Strong EvidenceExcellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.
Black Seed Oil
Grade B — Moderate EvidenceWidely studied traditional remedy with strong anti-inflammatory properties from thymoquinone. Evidence for metabolic health, immune modulation, and gut health. Oil form preferred for absorption.
Stinging Nettle Root
Grade B — Moderate EvidenceRoot extract may increase free testosterone by inhibiting SHBG binding. Evidence for prostate health and urinary symptoms. Root and leaf have different active compounds and uses. Very safe profile.
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⚕️ Important Disclaimer
This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.
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