Stinging Nettle Root

Also known as: urtica dioica, nettle root, nettle leaf

Grade B — Moderate Evidencebotanicalhormoneanti-inflammatory
300–600 mgMorning or split AM/PM

Stinging nettle root (Urtica dioica) contains lignan compounds that bind to sex hormone-binding globulin (SHBG), potentially increasing free testosterone levels. It is most commonly used alongside saw palmetto for benign prostatic hyperplasia (BPH), with clinical trials showing improvements in urinary symptoms. Nettle root also demonstrates anti-inflammatory properties through inhibition of 5-alpha reductase and aromatase, and has been studied for allergic rhinitis due to its natural antihistamine effects.

TL;DR: Root extract may increase free testosterone by inhibiting SHBG binding. Evidence for prostate health and urinary symptoms. Root and leaf have different active compounds and uses. Very safe profile.

🧬Longevity🛡️Immunity💪Muscle & Recovery
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade B

Studies

2

Interactions

3

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

LithiumModerate

Nettle may have diuretic effects — could increase lithium levels.

Diabetes medicationsLow

May lower blood sugar — monitor glucose.

Blood pressure medicationsLow

May have mild hypotensive effects.

Important Notes

  • Root extract (not leaf) is studied for hormonal effects
  • Leaf extract is studied for allergy/anti-inflammatory effects — different uses
  • Generally very well-tolerated

Clinical Evidence (2 studies)

Nettle root and SHBG binding

Schottner M et al. (1997) — Planta Med

Nettle root lignans inhibit SHBG binding to its receptor, potentially increasing free testosterone availability

View on PubMed

Urtica dioica for BPH symptoms

Safarinejad MR (2005) — J Herb Pharmacother

Nettle root 600mg/day for 8 weeks significantly improved urinary symptoms vs placebo in BPH patients

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Stinging Nettle Root.

Bromelain

Grade B

Proteolytic enzyme from pineapple with evidence for reducing inflammation, swelling, and pain. Comparable to NSAIDs in some studies. Must take on empty stomach for systemic effects.

💪 Muscle & Recovery🛡️ Immunity

Ginger

Grade A

Excellent evidence for anti-nausea effects (pregnancy, chemotherapy, post-op). Also anti-inflammatory with COX-2 inhibition.

🛡️ Immunity

Curcumin

Grade B

Potent anti-inflammatory from turmeric. Must enhance bioavailability with piperine or specialized formulations.

🧬 Longevity

Related Supplements

Vitamin D3

Grade A — Strong Evidence

Essential hormone precursor. Most people in northern latitudes are deficient. Strong evidence for immunity, bone health, and mood.

Bromelain

Grade B — Moderate Evidence

Proteolytic enzyme from pineapple with evidence for reducing inflammation, swelling, and pain. Comparable to NSAIDs in some studies. Must take on empty stomach for systemic effects.

NAC (N-Acetyl Cysteine)

Grade B — Moderate Evidence

Precursor to glutathione (master antioxidant). Strong evidence for respiratory health, liver support, and psychiatric conditions.

Zinc

Grade A — Strong Evidence

Essential mineral for immune function, wound healing, and testosterone production. Lozenges reduce cold duration by ~33%.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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