Saw Palmetto

Also known as: serenoa repens, sabal serrulata

Grade B — Moderate Evidencebotanicalhormone
160–320 mgWith fat-containing meal

Saw palmetto (Serenoa repens) berry extract inhibits 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT), making it the most studied herbal treatment for benign prostatic hyperplasia (BPH). Meta-analyses show improvements in urinary flow rate, frequency, and nocturia. While some large trials have questioned its efficacy, liposterolic extracts standardized to 85-95% fatty acids (at 320mg/day) show the most consistent clinical benefit.

TL;DR: Palm berry extract with evidence for prostate health and DHT reduction. May help with hair loss via 5-alpha reductase inhibition. Standardized extract at 320mg is the well-studied dose.

🧬Longevity✨Skin & Hair
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade B

Studies

2

Interactions

3

Forms

1

Evidence Rating: Grade B — Moderate Evidence

Some RCTs with positive results, or strong observational evidence. More research may refine our understanding.

Interaction Warnings

AnticoagulantsModerate

May increase bleeding risk — avoid with blood thinners.

Hormone therapiesModerate

Anti-androgenic effect may interact with hormonal treatments.

Finasteride/dutasterideModerate

Additive 5-alpha reductase inhibition — discuss with doctor before combining.

Important Notes

  • Most evidence is for prostate/urinary health in men
  • Standardized extract (85-95% fatty acids) is most studied
  • May take 4-6 weeks to see effects

Clinical Evidence (2 studies)

Serenoa repens for benign prostatic hyperplasia

Tacklind J et al. (2012) — Cochrane Database Syst Rev

Evidence suggests mild improvement in urinary symptoms; similar efficacy to finasteride with fewer sexual side effects

View on PubMed

Saw palmetto and 5-alpha reductase inhibition

Habib FK et al. (2005) — J Steroid Biochem Mol Biol

Saw palmetto extract inhibits 5-alpha reductase and reduces DHT levels without affecting total testosterone

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of Saw Palmetto.

DIM (Diindolylmethane)

Grade C

Metabolite of cruciferous vegetables that promotes favorable estrogen metabolism. Shifts estrogen toward less potent metabolites. Research primarily in hormone balance and cancer prevention.

🧬 Longevity✨ Skin & Hair

Black Seed Oil

Grade B

Widely studied traditional remedy with strong anti-inflammatory properties from thymoquinone. Evidence for metabolic health, immune modulation, and gut health. Oil form preferred for absorption.

✨ Skin & Hair

Milk Thistle

Grade B

Premier liver-support herb with strong evidence for hepatoprotection. Silymarin (active compound) has antioxidant, anti-inflammatory, and regenerative effects on liver cells. Phytosome form preferred.

🧬 Longevity

Related Supplements

DIM (Diindolylmethane)

Grade C — Preliminary

Metabolite of cruciferous vegetables that promotes favorable estrogen metabolism. Shifts estrogen toward less potent metabolites. Research primarily in hormone balance and cancer prevention.

Vitamin C

Grade A — Strong Evidence

Essential antioxidant vitamin. Supports immune function, collagen synthesis, and antioxidant defense. 50% infection reduction in athletes.

Selenium

Grade B — Moderate Evidence

Essential trace mineral for thyroid function (T4→T3 conversion) and antioxidant defense. Reduces Hashimoto's antibodies.

Lutein

Grade B — Moderate Evidence

Carotenoid concentrated in the retina and brain. Strong evidence for eye health; emerging evidence for cognitive function.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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