DIM (Diindolylmethane)

Also known as: diindolylmethane, 3,3'-diindolylmethane

Grade C — Preliminaryhormonedetox
100–300 mgWith fat-containing meal

DIM (3,3'-diindolylmethane) is a compound formed from the digestion of indole-3-carbinol, found in cruciferous vegetables, that modulates estrogen metabolism by shifting the ratio toward favorable 2-hydroxy estrogen metabolites over the potentially harmful 16-hydroxy and 4-hydroxy pathways. It is used for estrogen balance in both men and women, with evidence for reducing estrogen dominance symptoms and supporting prostate health at doses of 100-200mg/day.

TL;DR: Metabolite of cruciferous vegetables that promotes favorable estrogen metabolism. Shifts estrogen toward less potent metabolites. Research primarily in hormone balance and cancer prevention.

🧬Longevity😊Mood✨Skin & Hair
Last reviewed: 2026-03-12

Quick Facts

Evidence

Grade C

Studies

2

Interactions

2

Forms

1

Evidence Rating: Grade C — Preliminary

Limited human trials, mostly animal or in-vitro data. Promising but not yet proven in robust human studies.

Interaction Warnings

Tamoxifen and hormone therapiesModerate

Alters estrogen metabolism — may interact with hormonal cancer treatments.

CYP1A2 substratesLow

DIM induces CYP1A2 enzyme — may increase metabolism of caffeine, theophylline.

Important Notes

  • Derived from cruciferous vegetables (broccoli, cauliflower)
  • May cause temporary darkening of urine — harmless
  • Women with estrogen-sensitive conditions should consult doctor first

Clinical Evidence (2 studies)

DIM and estrogen metabolism in humans

Dalessandri KM et al. (2004) — J Nutr

DIM 108mg/day significantly increased 2-hydroxyestrone:16a-hydroxyestrone ratio (favorable estrogen metabolism) in postmenopausal women

View on PubMed

Indole-3-carbinol and diindolylmethane in cancer prevention

Weng JR et al. (2008) — Cancer Lett

DIM promotes beneficial estrogen metabolism and shows anti-proliferative effects in hormone-sensitive cancer cell lines

View on PubMed

Alternatives to Consider

These supplements target similar goals and may be worth considering alongside or instead of DIM (Diindolylmethane).

Saw Palmetto

Grade B

Palm berry extract with evidence for prostate health and DHT reduction. May help with hair loss via 5-alpha reductase inhibition. Standardized extract at 320mg is the well-studied dose.

🧬 Longevity✨ Skin & Hair

Sulforaphane

Grade B

Powerful Nrf2 activator from cruciferous vegetables. Evidence for air pollution detoxification and H. pylori eradication.

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Maca Root

Grade B

Peruvian adaptogen with evidence for libido, mood, and energy. Does not directly affect hormones but may modulate endocrine function. Black and red varieties have different benefit profiles.

😊 Mood

Related Supplements

Saw Palmetto

Grade B — Moderate Evidence

Palm berry extract with evidence for prostate health and DHT reduction. May help with hair loss via 5-alpha reductase inhibition. Standardized extract at 320mg is the well-studied dose.

Vitamin D3

Grade A — Strong Evidence

Essential hormone precursor. Most people in northern latitudes are deficient. Strong evidence for immunity, bone health, and mood.

Omega-3 Fish Oil

Grade A — Strong Evidence

Essential fatty acids with strong evidence for cardiovascular and mental health. EPA-dominant for mood; triglyceride form for absorption.

NAC (N-Acetyl Cysteine)

Grade B — Moderate Evidence

Precursor to glutathione (master antioxidant). Strong evidence for respiratory health, liver support, and psychiatric conditions.

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⚕️ Important Disclaimer

This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.

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