Wobenzym (Systemic Enzymes)
Also known as: systemic enzymes, proteolytic enzymes, wobenzym n, bromelain-trypsin combination
Recommended Dosage
3–6 tablets
Enteric-coated blend of proteolytic enzymes (bromelain, trypsin, rutosid) with evidence for joint pain relief comparable to NSAIDs in some studies. Must be taken on empty stomach for systemic absorption. Generally well tolerated. Avoid near surgery.
Quick Facts
Evidence
Grade C
Studies
1
Interactions
2
Forms
1
Evidence Rating: Grade C — Preliminary
Limited human trials, mostly animal or in-vitro data. Promising but not yet proven in robust human studies.
Interaction Warnings
Proteolytic enzymes may increase bleeding risk via fibrinolytic activity.
May increase antibiotic absorption and tissue levels — generally considered beneficial.
Important Notes
- Must be taken on empty stomach — food neutralizes enzyme activity
- Contains a blend of bromelain, trypsin, and rutosid (rutin)
- Enteric coating is essential — stomach acid destroys uncoated enzymes
- Avoid before surgery due to potential bleeding risk
- May cause mild GI upset initially
Clinical Evidence (1 study)
Efficacy and safety of systemic enzyme therapy vs diclofenac in knee osteoarthritis
Akhtar NM et al. (2004) — Clin Rheumatol
Oral enzyme therapy was comparable to diclofenac for pain relief in knee OA with fewer GI side effects
View on PubMedAlternatives to Consider
These supplements target similar goals and may be worth considering alongside or instead of Wobenzym (Systemic Enzymes).
Bromelain
Grade BProteolytic enzyme from pineapple with evidence for reducing inflammation, swelling, and pain. Comparable to NSAIDs in some studies. Must take on empty stomach for systemic effects.
Stinging Nettle Root
Grade BRoot extract may increase free testosterone by inhibiting SHBG binding. Evidence for prostate health and urinary symptoms. Root and leaf have different active compounds and uses. Very safe profile.
Glucosamine
Grade BBuilding block for cartilage with solid evidence for knee osteoarthritis pain and function. Glucosamine sulfate is the preferred form. Takes weeks to show benefit. Safe long-term with few interactions.
Related Supplements
Bromelain
Grade B — Moderate EvidenceProteolytic enzyme from pineapple with evidence for reducing inflammation, swelling, and pain. Comparable to NSAIDs in some studies. Must take on empty stomach for systemic effects.
Stinging Nettle Root
Grade B — Moderate EvidenceRoot extract may increase free testosterone by inhibiting SHBG binding. Evidence for prostate health and urinary symptoms. Root and leaf have different active compounds and uses. Very safe profile.
Glucosamine
Grade B — Moderate EvidenceBuilding block for cartilage with solid evidence for knee osteoarthritis pain and function. Glucosamine sulfate is the preferred form. Takes weeks to show benefit. Safe long-term with few interactions.
Chondroitin
Grade B — Moderate EvidenceMajor component of cartilage with evidence for osteoarthritis symptom relief. Often combined with glucosamine for synergistic benefit. Pharmaceutical-grade chondroitin sulfate (as used in European studies) may be more effective than many OTC products.
🧪 Get Your Personalized Stack
See how Wobenzym (Systemic Enzymes) fits with your goals and current supplements — AI-powered, evidence-graded recommendations.
⚕️ Important Disclaimer
This information is for educational purposes only. It is not medical advice. Always consult a healthcare provider before starting any supplement regimen, especially if you take medications or have health conditions.
DoseGrade does not sell supplements and has no affiliate relationships with supplement manufacturers.